The only full sibling of Alexander the Great. Cleopatra was married to her uncle, Olympias' brother, and at the wedding her father, Philip II, was assassinated.

While her husband was off fighting in the south of Italy to help the Greek colony Tarent, Cleopatra ruled in Epirus. When her husband was killed by the Tarentians, Olympias returned to Epirus and persuaded her daughter to leave the monarchy to her.

In 325 Cleopatra went back to Macedonia. When her brother died two years later, several of his generals wanted to marry her.

She then fled to Sardis, where Antigonos Monophtalmos held her captive. When she tried to flee to Ptolemaios I Antigonos had her killed.